Chunk #70 — Online Methods — CSF biomarker association analysis

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A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.

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For the CSF datasets, we performed multivariate linear regression for CSF Aβ42 and tau, and ptau181 association adjusting for age, gender, site, and the first three principal components using PLINK.