Second, moderate alcohol intake favourably affects coagulation profiles [84], in particular through its effects on platelet aggregation [131] and fibrinolysis [132]. A meta-analysis of 42 published short-term trials confirmed the influence of alcohol both on serum lipid profiles and on blood-clotting factors [84]. Other mechanisms for the cardioprotective effect of light to moderate consumption have been discussed [117;129] but, based on current knowledge, appear to play less prominent roles in explaining the beneficial effects of regular light to moderate drinking.