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Chunk #33 — Online Methods — Estimation of hγ2

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Leveraging population admixture to characterize the heritability of complex traits.
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We use a variance components approach to determine the phenotypic variance described by local ancestry hγ2 using θ as a fixed effect to prevent confounding from environmental factors association with ancestry. This method is equivalent to recent methods used to determine the phenotypic variance described by genotyped SNPs ( hg2), replacing genotypes with inferred local ancestry10.