To determine the relationship between detectable mosaic autosomal abnormalities and non-hematological cancers, we regressed the presence of detectable clonal mosaicism on cancer diagnosis, age, sex, DNA source, smoking and ancestry in a logistic model. We observed a modest increase in cancer risk for mosaic individuals (OR=1.27, 1.05-1.52 95% CI, p=0.012) (Tables 2 & Supplementary Table 2). Notable associations were observed in stratified analyses of lung (OR=1.56, 1.18-2.08 95% CI, p=0.002) and kidney (OR=1.98, 1.27-3.06 95% CI, p=0.002) cancers, both tobacco-associated malignancies. However no cancer site-specific associations were observed for bladder, esophagus, stomach and pancreas cancers, which are also typically associated with tobacco use. There was no significant association in non-hematological cancer cases overall between smoking (ever/never) and frequency of mosaicism (OR=1.19, 0.92-1.54 95% CI, p=0.19) or when stratified by cancer site (results not shown).
