The SOS Sib Pair Study cohort was as previously published21. It includes 154 nuclear families, each with BMI discordant sibling pairs (BMI difference >10 kg.m−2), giving a total of 732 subjects. Genotyping data using the Illumina 610K-Quad array was available for 353 siblings from 149 families. Expression data from subcutaneous adipose tissue (sampled after overnight fasting) were available for 360 siblings from 151 families. Subjects received written and oral information before giving written informed consent. The Regional Ethics Committee in Gothenburg approved the studies.
