Chunk #42 — ONLINE METHODS — Bayesian framework for calculating winner’s-curse-adjusted posterior effect-size distributions.

Source

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

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To calculate the 5th, 50th, and 95th percentile of the effect-size distribution of our lead SNPs, we simulated effect sizes from each lead SNP’s posterior distribution and identified the 5th, 50th, and 95th percentiles of the complete set of simulated effect sizes.