GABAB receptors have been implicated in regulation of alcohol drinking. The positive allosteric modulator, GS39783, suppresses alcohol drinking and reinforcement in rats (1). A GABAB receptor agonist, gamma-hydroxybutyrate, can reduce voluntary ethanol drinking and withdrawal symptoms in humans and is a treatment for alcoholism (2, 3). Another agonist, baclofen, may also be effective in treating the disease (4).
