Detailed descriptions of CATS data collection have been reported.6,7,20 Opioid dependent individuals, aged 18 or older, were recruited from opioid substitution therapy (OST) clinics in the greater Sydney region. Neighborhood controls, individuals with little or no lifetime opioid misuse, were recruited from socially disadvantaged neighborhoods in geographic proximity to OST clinics. Written informed consent was obtained from all participants as approved by the institutional review boards (IRBs) of all participating institutions and clinics. Semi-structured psychiatric diagnostic interviews, a modified Semi-Structured Assessment for the Genetics of Alcoholism - Australia (SSAGA-OZ),30 were completed in-person.
