Chunk #23 — Limitations and misunderstandings of clinical, translational, and research applications of PRS — Eurocentric GWAS biases limit the generalizability of genetic risk prediction
highly heritable, some environmental factors can dwarf individual genetic effect sizes and create issues of comparability across diverse populations. Critically needed statistical methods are being developed to improve the generalizability of genetic risk scores across diverse populations, including our own and others (62). Analytical methods alone are unlikely to provide a complete fix, however. Without a massive investment to perform similarly sized GWAS in globally diverse populations, PRS across all diseases are much more likely to benefit European ancestry populations already on the positive end of health disparities.
