closest m controls to each case, where m = 5 and 10. For SNPs in the HLA region, we evaluated mCLRs success at detecting association with T1D. From our results it is apparent that as m increases our power to detect certain SNPs increases (Figure 7). The best p-value is over an order of magnitude better for m = 10 than m = 0 and well over 2 orders of magnitude better when using all of the controls. The strongest signals occur at SNPs rs241427 and rs9273363 located near the confirmed T1D susceptibility locus HLA-DQB1 within the HLA class II region [36].
