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Chunk #32 — Results — Decreased Neurotransmitter-Specific Gene Expression During Adolescent Brain Maturation and Binge Ethanol Treatment

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Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice.
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two individual genes were suppressed persistently at P148 following young adult binge ethanol treatment (P88-P97): CCKα and Galantin receptor 2 (Table 2; 56% and 55% reduction respectively, *p<0.05 t-test). The statistical significance of these two reductions was lost after Bonferroni correction for multiple comparisons (Table 2). These findings indicate that adolescent binge ethanol treatment causes more pronounced and persistent decreases in brain neurotransmitter-specific gene expression than young adult binge ethanol treatment.