While association with rs9804190 is sufficient in itself to demonstrate a role of ANK3 in PTSD and externalizing, we expanded our search to the full set of SNPs spanning the ANK3 locus, and found several that were more significantly associated with externalizing or PTSD prior to multiple testing correction. Figure 1 displays association results of all examined ANK3 SNPs. Table 1 summarizes the results of those SNPs with nominal (uncorrected) p-values of <0.01 for either externalizing or PTSD. In brief, 4 SNPs (Table 1, SNPs 1 to 4) were associated with externalizing at the p<0.01 level (from chr10: 61,789,272 to 61,793,520 bp), just upstream and leading into the 3′ UTR (as ANK3 is coded on the reverse strand) (Figure 1). The most significant association observed in this region occurred at rs1049862 in the 3′ UTR (p=0.00040). The simulation-based corrected p-value narrowly missed significance when the 358 SNPs examined within the gene were simultaneously considered (pcorrected=0.060). None of the SNPs that were associated with externalizing at the p<0.01 level were associated with PTSD (all p>0.15). When we examined ANK3 for association
