Secondary GWAS Adjusted for BMI: As described below, for both alcohol-related traits, we identified a GWS SNP in FTO, variation in which has been associated with BMI and risk of obesity67. To examine whether BMI confounded the association with this and other loci and the genetic correlations with other traits, we repeated the GWAS for AUDIT-C and AUD using BMI as an additional covariate. Data on BMI were from the MVP baseline survey and the EHR. For AUDIT-C, 200,092 EAs; 56,239 AAs; 14,029 LAs; 1352 EAAs; and 185 SAAs had BMI data available. For AUD, 201,320 EAs; 56,347 AAs; 14,075 LAs; 1360 EAAs; and 186 SAAs had BMI data available. After GWAS, we analyzed the genetic correlations between BMI-adjusted traits and other publicly available traits (N = 714), with Bonferroni correction for multiple testing.
