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Chunk #13 — Results — Widespread differences in gene expression in diverse cell types are associated with AUD

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Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder.
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type and the resulting higher statistical power, D1 and D2 MSNs had a markedly lower number of DEGs than other cell types with a similar number of reads (Fig. 2b). Many of the DEGs were differentially expressed in multiple cell types; notably, astrocytes and oligodendrocytes had 315 DEGs in common, and D1 and D2 neurons had 247 DEGs in common (Supplementary Fig. 5a).