There are several strengths of this study. We replicated common genetic variation in a sample, which also includes detailed environmental information. In addition, we used a relatively novel polygene score–environment interaction method, which allowed a focus on the social context in this study. We examined one commonly studied social context (traumatic life events) and two novel aspects of the individual's neighborhood (social cohesion and physical disorder). Most importantly, this is a unique sample collected for the study of genetic and environmental influences on mental health and related traits in a population primarily of non-European ancestry.
