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Chunk #6 — 2. MATERIAL AND METHODS — 2.3. Genotyping

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Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
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Genotyping was performed at the Genome Technology Access Center at Washington University School of Medicine in St. Louis (http://gtac.wustl.edu/) using the Illumina Human OmniExpress array 12.VI (Illumina, San Diego, CA, USA). A total of 707,557 autosomal SNPs passed quality control (Wang et al., 2013). SNPs with a minor allele frequency (MAF) below 5% (n=115,872) were excluded from further analysis. EIGENSTRAT was utilized in the HapMap European reference samples to identify ethnic stratification within the sample.