Chunk #19 — Neurocognitive and Neurobiological Effects of Acute Nicotine Exposure and Withdrawal — Acute Nicotine Consumption, Nicotine Withdrawal and Neurobiological Function
as decreases in cerebellum and occipital lobes that were associated with plasma nicotine levels [18,114,115]. Some studies report a 7–10% decrease in global glucose utilization following acute nicotine administration in chronic smokers deprived of nicotine for 8 hours or more [116,117]. Depending on the nature of the task, results suggest acute nicotine administration in smokers and non-smokers is associated with increased regional blood flow/brain activity and improves task performance or decreases blood flow/oxygenation level-dependent activity and task performance [18,20]. As discussed by Sharma and Brody [22], the reported regionally specific findings may be influenced by whether or not activity was standardized to whole brain blood flow.
