We also assessed whether the three genetic factor scores underlying AD were differentially associated with putative external validators. The three factors differed significantly in their prediction of nearly all of these validators and formed a coherent pattern of associations. The loss of control/social dysfunction genetic factor was most strongly related to other psychopathology and treatment seeking for AD, whereas the tolerance/excess drinking factor predicted age of drinking onset and maximum daily consumption. Their ability to differentially predict a set of relevant external validators supports the validity of these three genetic factors.
