We tried to minimise reporting bias by including all events (such as deaths) reported regardless of whether or not we considered them to be related to treatment. It is still possible, however, that reporting bias could have occurred as for certain trials, where the corresponding authors did not respond to our requests for additional information, we could not determine whether a lack of reporting of deaths in the published paper was synonymous with no deaths. It was difficult to interpret the funnel plots to assess whether publication bias might be present as most trials were efficacy trials and were not performed solely to determine the incidence of psychiatric adverse events.
