genetic correlations between the major adult disorders are true, then overlapping symptoms and misdiagnosis among these disorders might be expected. The rg SNP value between schizophrenia and major depressive disorder is also unlikely to reflect misdiagnosis because misclassification between these disorders is rare49. Excluding 5 of the 18 PGC schizophrenia cohorts containing schizoaffective disorder cases21 (Supplementary Table 7) or major depressive disorder cohorts ascertained from community rather than clinical settings (Supplementary Table 8) had little impact on rg SNP estimates.
