As a simple metric of whether or not the incorporation of SNP x rAOS or other interaction terms into the genetic models would result in improved model fits, we talliled the number of SNPs that met traditional significance thresholds (<0.05, <0.01 and <0.001) in the main effect and interaction models The p-values were those derived from the main effect model (equation 2) and the joint p-value for the main effect and interaction terms from the interaction model (Equation 3). Overall false-discovery rates (π0 parameters) were also computed for each set of analyses using the program QVALUE (Storey 2002). The π0 parameter is an estimate of the total proportion of false-positives in the complete distribution of p-values if the null hypothesis is rejected for all tests.
