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Chunk #0 — Introduction

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Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes.
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Attention-deficit/hyperactivity disorder (ADHD), the most common neuropsychiatric disorder in children, with a 5.2% worldwide pooled prevalence rate,1 causes significant academic, behavioral and social impairment throughout the life span.2, 3 The phenotype consists of extreme manifestations of continuous traits, including hyperactivity, impulsivity, and dysfunction in executive and self-regulatory skills that involve working memory, temporal organization, planning, organizing, maintaining focus, effort and motivation.4, 5