only significant in a single tissue, examination of the correlation between the same SNP and trait in other tissues generally reveals a suggestive, although non-significant, correlation in the other tissues; thus both large and many moderate size effects appear to be shared. While this aspect of our data may seem at odds with the previous studies which in part used purified cells or cell lines, the current samples within our study were exclusively from heterogeneous tissues. Thus one might expect to see quantitative trait loci that are generalizeable across tissues because in essence each tissue is a heterogeneous mix of cells and we are more likely to detect QTLs that are in a majority of cell types. The detection of cell type specific QTLs is apparently still feasible, however, such correlations will have to be large enough to detect within the background of a heterogeneous tissue.
