One region that interacts with the hippocampus is the medial prefrontal cortex (mPFC). The mPFC is important for working memory, as well as executive functions including decision-making, goal-oriented behaviors, and attentional selection of task-relevant information [7]. The mPFC receives direct projections from ventral CA1 and subiculum subfields of the hippocampus [8,9], and these synapses are plastic [10]. The hippocampus is believed to activate mPFC during behaviors in which functions of mPFC are required. For example, the hippocampus may encode a memory of a particular circumstance that is associated with a particular goal-directed behavior. When this circumstance arises later, the hippocampus may retrieve its memory of this circumstance and communicate to the prefrontal cortex so that behavior can be adjusted to achieve the desired goal.
