Signaling in response to genotoxic stress is specific to the type of stress and the nature of DNA damage. For example, the most lethal type of damage induced by IR exposure is DSBs, whereas UV radiation exposure induces CPDs and other types of DNA damage. Therefore, it is not surprising that regulation of Wip1 and Wip1 signaling after UV radiation exposure is different than after IR exposure. Several recent studies have focused on elucidating Wip1 signaling after UV radiation exposure, which will be discussed in this section.
