The other two SNPs meeting genome-wide significance were intergenic and located on chromosomes 11 and 13. The SNP rs7950811, on chromosome 11q14.3, is located at the edge of the gene LOC642791, which is similar to elongation factor 1-α; EF-1-α. The other SNP, rs11838918, on 13q31.1 is ~13 kb from the nearest gene RP11–600P1.1/ LOC647298, a heat-shock 60-kDa protein 1 pseudogene. None of the SNPs significant at P < 10−5 in our GWAS represents an obvious candidate for involvement in CD. We used the online databases ToppGene37 and DAVID38 to assess whether our list of genes containing significant markers is functionally enriched for gene ontology categories, and whether these genes have been previously implicated in human phenotypes. Using an FDR cutoff of P < 0.05, the only enriched gene ontology category among genes implicated in the current report is the molecular function ‘magnesium ion binding’, which applies to two genes (ERCC4 and PDE10A). We further investigated potential commonalities among significant genes using the BioGPS online database. Six of the genes (ARHGAP22, ERCC4, NAG, SELPLG, TOX2 and ZNF330) are highly expressed in
