times to foot shock between the human glial chimeras and their rag 1-null immunodeficient controls (n=5, 9.6 ± 0.95 month, F = 0.08 by two-way ANOVA, p>0.5) (Fig. S5A). Moreover, neither thermal nor mechanical sensitivity were affected by chimerization of either rag1 or rag2 mice (Figs. S5D-E), suggesting that their respective nociceptive thresholds were analogous.
