The Finns and Plains Indians have in common three long-distance haplotypes: H1, H3 and H4 (see Figure 5). These ancestral haplotypes accounted for 0.57 of the long-distance haplotype diversity in Finns and 0.31 of diversity in the Plains. In both populations, H1 is associated with AUD and H3 and H4 are more abundant in non-alcoholics (Fig 5). Haplotypes H3 and H4 have very nearly opposite configuration to haplotype H1.
