We used genotypes for 379 individuals from the EUR-1KG cohort[22]. Corresponding phenotype values were simulated as independent, standard normally distributed variables. Univariate Z-scores for each of the 2,692,429 tested SNPs were calculated using linear regression. Simulations were repeated 100 times. Since we investigated the impact of gene-fusion, the LD matrix was estimated from the same data set to avoid any influence that might come from out-of-sample LD estimation.
