In about 30% of schizophrenic patients, persistent subplate neurons have been found.26,27 As their disappearance is important for the maturation of thalamocortical connections, some authors have raised the point that this might be an example of erroneous connections, ie, persistent connection with subplate instead of layer 4 neurons. Pyramidal cell disarray in internal temporal cortices28 could also be accompanied by such abnormalities of connectivity. However, many of these results have been hard to replicate, and the false target hypothesis remains speculative, although interesting to look into. Both local and long-range reductions in anatomical connectivity, together with possible erroneous connections, have led several authors to rejuvenate the “sejunction hypothesis” under the updated appellation of disconnéetivity.27,29-33
