We evaluated the distribution of three SNPs in BCHE in a sample of cocaine-dependent patients and controls in Brazil. For the SNP rs4263329, there was a nominal association between patients and controls [GG genotype, P = 0.05, OR = 2.3; 95% CI = 0.99–5.32]. We also found a significant association between rs1803274 and crack cocaine (AA genotype) as the preferred route of administration (p<0,005). To our knowledge, this is the only report in the literature investigating BCHE variants and crack/cocaine.
