individuals who were homozygous for this allele (Dick, Agrawal, et al., 2006). These data suggested that the A allele (the T allele on the complementary strand examined in the current study) could potentially be a risk allele for early initiation of alcohol. The SNP rs279871 is in high linkage disequilibrium with other SNPs across GABRA2 and captures the majority of genetic variability across the gene (Edenberg et al., 2004). It is therefore optimal in the proposed model. Although the GABRA2 studies cited above show an association of this SNP with several problematic alcohol-use related phenotypes, other recent studies have also suggested a potential relationship between rs279871 and disruptive behavior in adolescence. Dick, Bierut, et al. (2006) have demonstrated an association between the A allele of this SNP (again, the T allele examined on the complementary strand in the current study) and the number of CD symptoms. However, in a later study, this group did not replicate this relationship but did demonstrate an association between this SNP and the YSR externalizing score (Dick, Aliev, Latendresse, Hickman, et al., 2013). This potential relationship between disruptive behavior and rs279871 builds upon our previous work demonstrating significance for both the number of CD symptoms
