Data analysis followed the logic presented in Figure 1. First, mouse ethanol response QTL were mapped in the recombinant inbred strain BXD, a strain constructed from the parental strains C57/B6 and DBA, which has been extensively phenotyped for alcohol-related behaviors. We limited our analysis to ethanol-induced ataxia as our ultimate goal was to compare the BXD result with human data. Ethanol-induced ataxia is a phenotypic measure held in common between mouse and human. All BXD data and QTL interval mapping were performed using the tools available on the genenetwork.org website as described in Materials and Methods. Twelve phenotypes comparable to the human body sway phenotype were present in the GeneNetwork database and were analyzed (Table 1).
