Genome-wide significant and suggestive genetic variants were associated with anthropometric indices, body composition and growth rate. The common nonsynonymous SNP rs1056513 in INADL accounted for 3% of the variance in body weight and body composition, and is highly conserved across mammalian species. INADL encodes a PDZ domain-containing protein thought to play a role in tight junctions and adipocyte differentiation [28]. Weight z-score change observed over one-year was associated with an intronic variant in COL4A1, which encodes a basement membrane collagen. Height change was associated with a 5′UTR variant inTSEN34, which is involved in tRNA splicing, a fundamental process required for cell growth and division [29].
