Single nucleotide polymorphism rs1497571 of the GABRG1 gene was also associated with drinking patterns in this sample, such that carriers of the T allele reported a lower average number of drinks per episode, over the past year [ACQ1; t(120) = 3.00, p < 0.01], lower maximum number of drinks per drinking episode over the past year [ACQ2; t(120) = 2.44, p < 0.05] and lower AUDIT Scores [AUDIT; t(120) = 2.31, p < 0.05] when compared with homozygotes for the C allele. However, SNP rs1497571 was unrelated to how often participants drank [ACQ3; t(120) = 1.11, p = 0.27], and their scores on the RAPI [RAPI; t(120) = 0.23, p = 0.81]. As shown by the correlations in Table 1, level of response to alcohol was significantly associated with a heavier drinking pattern and more alcohol-related problems. Finally, restricting the analyses to individual who have valid genotypes for both SNPs of interest (n = 112) did not alter the results reported above.
