Genotyping the families for the SNPs rs2302382 and rs8111428 was performed using Matrix-assisted desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) as described earlier [28]. SNP rs1800437 (a) was genotyped using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis. Additional genotypes for SNPs rs2302382 (b) and rs8111428 (c) were performed using ARMS-PCR as described previously (16): (a) rs1800437: F 5'-ATT ACC GGC TGA GGT GAG G-3' and R 5'-CTG GAA GGA GCT GAG GAA GA-3' digested with BssSI (C-allele 245 bp, G-allele 150 and 94 bp). (b) rs2302382: Fo 5'-CAG CGT AGC TCT AGG GCA ACC GCC CGC T-3' and Ro 5'-GAT CAG GCC TGG AGG GTC CCA GGG CAA G-3':324 bp; Fi 5'-CCA CTC CGC GTG CCT CTC CCT CCT CC-3' and Ri 5'-CCG CAA CTC CCA GGC GTG ATG ATC CGT-3' (C-allele 200 bp, A-allele 177 bp). (c) rs8111428: Fo 5'-AAA GGA ACA GAC TGG AAG TAG AGA CAG-3' and Ro 5'-TTT ATG ACA CAA GCT GAA AGT CAC AC-3':486 bp; Fi 5'-TGT ATA TGA CTG TAT GTG ACT TGT GAC TG-3' and Ri 5'-CAC AAC TCT CCC TTA
