These authors also studied the effect of cannabinoid receptor activity on medial prefrontal cortex (mPFC) stimulation-induced BLA neuron responses (Pistis et al., 2004). Stimulation current was adjusted such that 50% of stimuli produced spiking activity in BLA neurons. Win 55212-2 reduced mPFC stimulation-induced spike probability in BLA neurons to 48% of control; an effect that was reversed by SR141716, but not AM251. HU-210 did not affect mPFC stimulation-induced spike probability in BLA neurons (Pistis et al., 2004).
