Taken together, these results demonstrate that extending the duration of GABA-induced depolarization specifically elicits DISC1-dependent regulation of dendritic development of new neurons through the mTOR pathway during early postnatal neurogenesis and provide further evidence on the requirement of concomitant depolarizing GABA signaling over an extended period for DISC1-dependent regulation of dendritic growth (Figures 5E to 5F and Table S1).
