We also divided the 220 cell-type-specific annotations into 10 groups: adrenal/pancreas, CNS, cardiovascular, connective/bone, gastrointestinal, immune/hematopoietic, kidney, liver, skeletal muscle, and other. We took a union of cell-type-specific annotations within each group, resulting in 10 new cell-type group annotations (for example, SNPs with any of the four histone modifications in any CNS cell type). We then repeated the cell-type-specific analysis described above with these 10 cell-type groups instead of 220 cell-type-specific annotations.
