Chunk #33 — Results — Identification of trans effects and conditioned co-expression analysis

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Complex nature of SNP genotype effects on gene expression in primary human leucocytes.

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We used the celiac disease dataset to assess whether significant trans-eQTLs could be identified (Spearman's rank correlation test P-Value < 1 × 10-12, FDR = 0.05). Two trans-eQTLs were detected: rs2318331 (mapping within COL22A1) with GI_48093066 (NBPF3) and rs12634559 (mapping downstream of IL1RAP) with GI_16306505 (CASP8AP2). However, these trans-eQTLs were not detected in the HapMap B cell line dataset, even after relaxing the nominal Spearman rank correlation P-value to 0.05.