Overall, although we did not detect any SNP that met genome-wide significance, we have assembled several different lines of evidence to prioritize SNPs and genes from among the results for further study. In a multi-stage follow-up to the GWAS, we: a) analyzed a set of top SNPs by analyzing transmission in a family sample, which provided additional support for some of the SNPs; b) determined which among the top SNPs were expressed in human brain; and c) determined which top SNPs are affected by exposure to alcohol in human LCLs. The convergence of evidence from the GWAS, family-based association analyses and the response of genes to ethanol exposure provides a set of interesting candidate genes for further analyses in larger samples.
