Investigating neurobiological processes in FHP individuals is an important approach for identifying risk factors for developing AUD.36 Several studies have identified differences in brain activation or brain morphology in specific neuroanatomical regions. Henderson et al.6 previously reported differences in brain morphometry—lower cortical thickness in portions of the frontal and parietal cortex—as well as poorer visuospataial (but not verbal) working memory in the FHP compared to FHN groups. In the present study, we used a data-driven, whole-brain approach that provides a method for examining connectivity within and between networks.
