A histogram of PRS in EA subjects from case and comparison families is shown in Figure 1. The distribution of PRS is shifted to the right in case subjects, although there is substantial overlap. The shift is not significant in the thresholded analysis (p = 4.43 × 10−4), but it is when calculated by PRS-CS (p = 2.89 × 10−6). A similar histogram for AA subjects is shown in Figure S2 (no significant shift by thresholded analysis or by PRS-CSx).
