Chunk #85 — Online Methods — 6. Differentially Methylated Regions (DMRs) and DNA methylation variation — 6.3 Additional DMR calls

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Integrative analysis of 111 reference human epigenomes.

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For studying breast epithelia differentiation, DMRs were called from WGBS, requiring at least 5 aligned reads to call differentially-methylated CpG, and at least 3 differentiallymethylated CpGs within a distance of 200 bp of each other44. For studying tissue environment vs. developmental origin, DMRs were called from MeDIP and MRE data using the M&M algorithm55.