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Chunk #51 — Discussion — An Enrichment of Associations Implies Shared Genetic Etiology

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Alcohol-related genes show an enrichment of associations with a persistent externalizing factor.
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limited to those with genetic risk for specific clinical manifestations of externalizing. Further work by other consortia, continued GWAS in larger samples, data from analyses using polygenic risk scores (e.g., Salvatore et al., 2015) and bioinformatics work will be necessary to prune this set of potential false positives, and to add additional candidates that may be related to the broad range of externalizing problems rather than to alcohol-related outcomes specifically.