The method was applied to two real data sets, one from Guam and the other from Kosrae. Both studies were approved by University of Washington Institutional Review board (IRB). The data set from Guam consisted of a genome scan for association in a case-control sample collected to complement a family-based linkage study. The disorder of cases has characteristics of both amyotrophic lateral sclerosis and parkinsonism combined with dementia and is prevalent in the Chamorros, the indigenous people of Guam. A sample of 140 cases and 88 age-matched Chamorro controls were available with no known relationships among these subjects at the time they were sampled. The markers consisted of a standard genome-scan panel of 402 multiallelic markers. For each pair of individuals, the kinship and inbreeding coefficients were estimated using the methods described above. For each marker, allele frequencies of cases and controls were compared using the standard and the corrected χ2 tests.
