on an alcohol consumption phenotype). Third, the polygenic scores derived here include only common variants in regions well tagged by the variants in the 1000 Genomes panel. Fourth, there are alternative enrichment (Finucane et al., 2015) and alternative polygenic scoring methods (e.g., LDpred; Vilhjalmsson et al., 2015). Some combination of these may provide additional avenues for optimizing the predictive ability of polygenic scores in the future.
