Summary statistics from the largest available discovery GWAS were used to represent genetic risk for each construct. These include four measures of problematic substance use or substance use disorder (SUD): 1) Problematic Alcohol Use8, 2) Problematic Tobacco Use12,13,18, 3) Cannabis Use Disorder15, 4) Opioid Use Disorder16 (described below). All GWAS summary statistics were filtered to retain variants with minor allele frequencies > 0.01 and INFO score > 0.90 for GSCAN12 and PGC15 and INFO score > 0.70 for the MVP8,16.
