In conclusion, discontinuation of MMT in this urban setting was associated with several social-structural exposures, including recent homelessness, incarceration, lack of social income assistance, as well as heavy opioid and comorbid substance use. Our findings propose several potential directions to support retention on MMT, including access to housing and outreach services to support low threshold methadone treatment, removal of financial barriers to accessing MMT, as well as efforts to support MMT continuation between community and custodial settings.