In conclusion, in a sample of patients with chronic schizophrenia we examined if genetic susceptibility to schizophrenia could predict symptom dimensions and cognitive performance. We did not find specific variants associated with symptom or cognitive dimensions. However, we found that PRS predicted a small amount of variance in positive and negative symptom dimensions and performance on working memory and vigilance tests. Some of our findings are consistent with the literature and extend these associations in the population with chronic schizophrenia. Given that these symptoms and deficits in cognitive domains contribute heavily to morbidity in schizophrenia, these findings hold promise to inform further research and potentially guide an objective approach to diagnosis and development of precise therapeutic interventions.
